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BITE

Posted by mocapnyc


 

Explainer Video Script

Cancer is the uncontrolled growth of abnormal cells inside the body. These cells divide without control and are able to invade other tissue

There are a number of different treatment types to combat cancer. One approach being studied is immunotherapy.

Cancer immunotherapy is designed to harness the body’s immune system to help fight cancer.

One kind of immunotherapy under investigation uses T cells. T cells, which are special white blood cells play a central role in the body’s immune system.

T cells typically help the immune system combat foreign invaders such as viruses, helping to prevent and fight illness. They also have the ability to fight cancer cells.

Cancer cells may evade the immune system, making them hard to detect. They develop inside the body and are usually able to disguise themselves, tricking the immune system into thinking they are healthy cells. Using a number of different mechanisms, cancer cells escape notice and destruction from the immune system and T cells.

Investigational BiTE® antibodies were developed to help T cells detect and locate cancer cells.

BiTE® antibodies are thought to work by bridging two targets found within close proximity to each other at the same time. One target is a receptor on T cells. The other target is a cancer-specific molecule.

BiTE® antibodies are then thought to bring T-cells in close proximity to cancer cells, allowing T-cells to recognize and destroy the cancer cell. The hypothesized goal is to trigger a response that will overcome the cancer cells’ ability to hide from the body’s immune system. Once the T cells use the bridge created by the BiTE® antibodies, they are close enough fight the cancer cells.

Amgen is investigating the ability of BiTE® antibodies to help T-cells recognize and continue to fight target cancer cells.